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When determining the size of the initial dose, Bear in mind that deaths from methadone overdose in the primary two weeks of treatment have occurred at doses as low as forty-60mg every day.Therapy must be ongoing provided that clinically meaningful advancement in pain/function outweighs risks. Therapy should be initiated at the bottom effective dosa

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CYP2B6 is The key CYP enzyme involved in the metabolism of S-methadone and also to an extent, R-methadone. The expression of CYP2B6You will discover plans to grow the methadone maintenance program to other prisons in Indonesia. The success of this pilot program has demonstrated that it truly is feasible to introduce methadone maintenance treatment

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